Primary sclerosing cholangitis.

نویسنده

L Tinckler

چکیده

PRIMARY sclerosing cholangitis, stenosing cholangitis, fibrosing cholangitis, chronic obliterative cholangitis are all terms referring to a rare diffuse type ofchronic inflammation of the entire common bile duct and at times of the hepatic ducts and their radicles. In most instances, sclerosing cholangitis is idiopathic or primary. Bartholomew et al., in 1963 found only twenty unequivocal cases reported in the previous 40 years and considered that the rarity of the syndrome and the poor results of treatment warranted reporting of individual cases, particularly if they provided new aetiological or therapeutic data. Although Schwartz & Dale (1958) described a diffuse obliterative ductal sclerosis in patients with gall-stone disease, stenosing cholangitis involving only a short segment of the common duct may occur and Baddeley & Stammers (1964) infer that such lesions may diffusely spread throughout the bile duct system. Glen & Witsell (1966) stipulate the following criteria for making the diagnosis: progressive biliary obstruction, exclusion of surgical injury as a possible causative agent, operative demonstration of a diffuse sclerosing process involving the common duct, frequently the hepatic ducts and sometimes the gall bladder, a fibrotic process and absence of malignant neoplasm requiring histological confirmation.

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